The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 17, 2026

Filed:

Apr. 21, 2023
Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Jesse Gordon-Blake, Chicago, IL (US);

Tom G. Driver, Chicago, IL (US);

Kiira Ratia, Chicago, IL (US);

Gregory R. Thatcher, Tucson, AZ (US);

Victoria Weidig, Chicago, IL (US);

Leon Tai, Chicago, IL (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 309/06 (2006.01); A61P 25/28 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 407/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07D 309/06 (2013.01); A61P 25/28 (2018.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01);
Abstract

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that increase the amount of nicotinamide adenine dinucleotide (NAD) in a subject. By raising the amount of nicotinamide adenine dinucleotide in a subject, diseases associated with reduced levels of nicotinamide adenine dinucleotide can be treated or prevented. In one aspect, raising the amount of NADin a subject can reduce or ameliorate one or more symptoms of Parkinson's disease, Alzheimer's disease, Huntington's disease, Multiple sclerosis, amylotrophic lateral sclerosis, AIDS-induced dementia, or epilepsy.


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