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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12551573 B1

PDFFull Text
Date of Patent:
Feb. 17, 2026

Filed:

Nov. 21, 2023

Compositions and methods for the targeting of pcsk9

Applicant:

Scribe Therapeutics Inc., Alameda, CA (US);

Inventors:

Jason Fernandes, Redwood City, CA (US);

Sean Higgins, Alameda, CA (US);

Sarah Denny, San Francisco, CA (US);

Ross White, Concord, CA (US);

Emeric Jean Marius Charles, Berkeley, CA (US);

Addison Wright, El Cerrito, CA (US);

Benjamin Demaree, Berkeley, CA (US);

Benjamin Oakes, El Cerrito, CA (US);

Assignee:

Scribe Therapeutics Inc., Alameda, CA (US);

Attorney:

COOLEY LLP

Primary Examiner:

Soren Harward

Assistant Examiner:

Jenna L Persons

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 9/10 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); C07K 14/4703 (2013.01); C12N 9/1007 (2013.01); C12N 9/22 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 15/88 (2013.01); C12N 15/907 (2013.01); C12Y 201/01037 (2013.01); C07K 2319/09 (2013.01); C07K 2319/80 (2013.01); C07K 2319/81 (2013.01); C12N 2310/20 (2017.05); C12N 2310/531 (2013.01);
Abstract

Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

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