The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 17, 2026

Filed:

Sep. 09, 2020
Applicant:

Scribe Therapeutics Inc., Alameda, CA (US);

Inventors:

Benjamin Oakes, El Cerrito, CA (US);

Sean Higgins, Alameda, CA (US);

Hannah Spinner, Boston, MA (US);

Sarah Denny, San Francisco, CA (US);

Brett T. Staahl, Tiburon, CA (US);

Kian Taylor, Atlanta, GA (US);

Katherine Baney, Berkeley, CA (US);

Isabel Colin, Oakland, CA (US);

Maroof Adil, Davis, CA (US);

Cole Urnes, Los Alamitos, CA (US);

Assignee:

Scribe Therapeutics Inc., Alameda, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/725 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/4211 (2025.01); A61K 48/005 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 14/7151 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01);
Abstract

Provided herein are CasX:gNA systems, and compositions and methods relating thereto, the systems comprising CasX proteins, guide nucleic acids (gNAs), and optionally donor template nucleic acids useful for the modification cell genes encoding proteins involved in antigen processing, antigen presentation, antigen recognition, and/or antigen response, as well as methods of producing and using populations of cells comprising these modified genes. In some embodiments, the modified cells further express chimeric antigen receptors (CAR) or engineered T cell receptors (TCR). Such systems are useful for preparing cells for immunotherapy.


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Quick Actions:

Oakes, Benjamin. (2026). Compositions and methods for use in immunotherapy (U.S. Patent No. 12551560). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12551560

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