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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12551500 B1

PDFFull Text
Date of Patent:
Feb. 17, 2026

Filed:

Jan. 03, 2025

C6'-substituted locked nucleic acid-modified cap analog and use thereof

Applicant:

Hangzhou Tianlong Pharmaceutical Co., Ltd., Zhejiang, CN;

Inventors:

Gengshen Song, Zhejiang, CN;

Honglei Zhang, Zhejiang, CN;

Yangjian Liu, Zhejiang, CN;

Kai Dong, Zhejiang, CN;

Jinyu Zhang, Zhejiang, CN;

Chuan Gao, Zhejiang, CN;

Lijie Jin, Zhejiang, CN;

Yuqing Li, Zhejiang, CN;

Huajie Huang, Zhejiang, CN;

Yanfen Li, Zhejiang, CN;

Limin Liang, Zhejiang, CN;

Xiaowen Yu, Zhejiang, CN;

Dawei Huang, Zhejiang, CN;

Assignee:

Hangzhou Tianlong Pharmaceutical Co., Ltd., Hangzhou, CN;

Attorney:
Primary Examiner:

Jane J Zara

Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61K 9/1272 (2025.01); A61K 9/51 (2006.01); A61K 47/42 (2017.01); C07H 21/02 (2006.01); C12N 9/12 (2006.01); C12N 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 9/1272 (2013.01); A61K 9/5123 (2013.01); A61K 47/42 (2013.01); C07H 21/02 (2013.01); C12N 9/1247 (2013.01); C12N 9/14 (2013.01); C12Y 207/07006 (2013.01); C12Y 306/01 (2013.01);
Abstract

The present disclosure provides a C6'-substituted locked nucleic acid-modified cap analog and a use thereof, wherein the cap analog improves the stability of mRNA and/or the translation efficiency of mRNA.

Find Patent Forward Citations

Song, Gengshen. (2026). C6'-substituted locked nucleic acid-modified cap analog and use thereof (U.S. Patent No. 12551500). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12551500

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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