The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2026

Filed:

Jun. 29, 2020
Applicant:

Kymera Therapeutics, Inc., Watertown, MA (US);

Inventors:

Nello Mainolfi, Belmont, MA (US);

Nan Ji, Arlington, MA (US);

Matthew M. Weiss, Boston, MA (US);

Xiaozhang Zheng, Lexington, MA (US);

Yi Zhang, Belmont, MA (US);

Paul R. Fleming, Lexington, MA (US);

Assignee:

Kymera Therapeutics, Inc., Watertown, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.


Find Patent Forward Citations

Mainolfi, Nello. (2026). Irak degraders and uses thereof (U.S. Patent No. 12545659). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12545659

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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