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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12545640 B1

PDFFull Text
Date of Patent:
Feb. 10, 2026

Filed:

Sep. 29, 2020

Substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof

Applicant:

Sanofi, Paris, FR;

Inventors:

Sabine Boisnard, Paris, FR;

Youssef El-Ahmad, Paris, FR;

Eykmar Fett, Paris, FR;

Frank Halley, Paris, FR;

Eric Nicolai, Paris, FR;

Michel Tabart, Paris, FR;

Corinne Terrier, Paris, FR;

Bertrand Vivet, Paris, FR;

Assignee:

Sanofi, Paris, FR;

Attorney:

McNeill PLLC

Primary Examiner:

Adam C Milligan

Assistant Examiner:

Ernesto undefined Valle

Int. Cl.
CPC ...
C07D 207/12 (2006.01); A61K 9/20 (2006.01); C07D 207/38 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 419/12 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07D 207/12 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); C07D 207/38 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 419/12 (2013.01); C07F 5/025 (2013.01);
Abstract

The present invention relates to a compound of the formula (i) wherein Ar represents a phenyl or a 6-membered heteroaryl group, R1 and R2 represent independently a hydrogen atom or a deuterium atom, R3 represents (1) a —COR4 group, (2) a —BOR5OR6 group, (3) a —X—Z group, (4) a (C-C)alkyl group or a (C-C)alkenyl group, (5) a —X—S(O)(R7)(R8)group, (6) a halogen atom, a —NHgroup or a —CN group, (7) a —O—R11 group, (8) a —NH—COR9 group, (9) a —C(═NH)NHOH group, (10) a —NH—C(NH)—R9' group, or (11) a —NHCOCOOR12 group or a —NHCOCONR12′R12″ group, X represents a bond, a —NH— group, a —CONH— group or a —CO— group, Z represents a 4 or 5-membered cycloalkyl, a 4 or 5-membered heterocylcloalkyl group, a 4 or 5-membered heteroaryl group or a phenyl group or a pharmaceutically acceptable salt thereof. The present invention further relates to a medicament comprising said compound of formula (I) and to said compound of formula (I) for use as an inhibitor and degrader of estrogen receptors.

Find Patent Forward Citations

Boisnard, Sabine. (2026). Substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof (U.S. Patent No. 12545640). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12545640

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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