The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2026

Filed:

Jan. 10, 2020
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Vamsi K. Mootha, Boston, MA (US);

Warren M. Zapol, Cambridge, MA (US);

Isha Jain, Cambridge, MA (US);

Luca Zazzeron, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 35/12 (2015.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 35/12 (2013.01); A61K 45/06 (2013.01); A61K 48/0091 (2013.01); A61P 25/00 (2018.01); C12N 15/113 (2013.01); A61K 2035/124 (2013.01);
Abstract

Methods for the treatment of disorders associated with mitochondrial dysfunction, including rare, inborn errors of metabolism caused by genetic mutations; neurodegenerative disease; diabetes; and aging and age-associated decline. Generally, the methods include administering a therapeutically effective amount of one or more treatments that (i) induce hemoglobin 'left-shifting' and/or (ii) induce anemia, as described herein, to a subject who is in need of, or who has been determined to be in need of, such treatment.


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