The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2026

Filed:

Nov. 10, 2021
Applicants:

Albert Einstein College of Medicine, Bronx, NY (US);

Washington University, St. Louis, MO (US);

Inventors:

Vladislav V. Verkhusha, Bronx, NY (US);

Andrii A. Kaberniuk, Bronx, NY (US);

Lihong Wang, St. Louis, MO (US);

Junjie Yao, St. Louis, MO (US);

Lei Li, St. Louis, MO (US);

Assignees:

Albert Einstein College of Medicine, Bronx, NY (US);

Washington University, St. Louis, MO (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 5/20 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0095 (2013.01); A61B 5/0037 (2013.01); A61B 5/201 (2013.01); A61B 5/7239 (2013.01); A61B 2576/02 (2013.01);
Abstract

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a first image obtained when the photoacoustic probe is in active (absorbing or ON) state and a second image obtained when the photoacoustic probe is in an inactive (less-absorbing or OFF) state. Subtraction of the second image from the first image is used to obtain the RS-PAT image.


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