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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12540922 B1

PDFFull Text
Date of Patent:
Feb. 03, 2026

Filed:

May. 10, 2022

Quantitative shotgun proteome, lipidome, and metabolome analysis by direct infusion

Applicants:

Wisconsin Alumni Research Foundation, Madison, WI (US);

The Medical College of Wisconsin, Inc., Milwaukee, WI (US);

Inventors:

Jesse Meyer, Milwaukee, WI (US);

Joshua Coon, Middleton, WI (US);

Alexander Hebert, Malvern, PA (US);

Caleb Cranney, Provo, UT (US);

Assignees:

Wisconsin Alumni Research Foundation, Madison, WI (US);

The Medical College of Wisconsin, Inc., Milwaukee, WI (US);

Attorney:

LEYDIG, VOIT & MAYER, LTD.

Primary Examiner:

Michael Maskell

Int. Cl.
CPC ...
G01N 27/64 (2006.01); G01N 27/623 (2021.01); G01N 27/624 (2021.01); H01J 49/00 (2006.01);
U.S. Cl.
CPC ...
G01N 27/64 (2013.01); G01N 27/623 (2021.01); G01N 27/624 (2013.01); H01J 49/0031 (2013.01); H01J 49/0036 (2013.01);
Abstract

The present invention provides methods and systems using gas-phase separation with mass spectrometry analysis instead of liquid chromatography, thereby enabling faster peptide, proteome, and multi-omic analysis. Also provided are improved methods and software for data independent acquisition. One embodiment referred to as Direct Infusion-Shotgun Proteome Analysis (DI-SPA) used with data-independent acquisition mass spectrometry (DIA-MS), resulted in targeted quantification of over 500 proteins within minutes of MS data collection (˜3.5 proteins/second). Enabling fast, unbiased protein and proteome quantification without liquid chromatography, DI-SPA offers a new approach to boosting throughput critical to drug and biomarker discovery studies that require analysis of thousands of proteomes. This invention is also able to perform complex multi-omic analysis of proteomes, lipidomes, and metabolomes on a single platform.

Find Patent Forward Citations

Meyer, Jesse. (2026). Quantitative shotgun proteome, lipidome, and metabolome analysis by direct infusion (U.S. Patent No. 12540922). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12540922

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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