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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12539512 B1

PDFFull Text
Date of Patent:
Feb. 03, 2026

Filed:

Feb. 24, 2023

Label-free quantification of cell surface membrane protein binding kinetics in biological systems

Applicant:

Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);

Inventors:

Shaopeng Wang, Chandler, AZ (US);

Fenni Zhang, Tempe, AZ (US);

Assignee:

ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);

Attorney:

MH2 Technology Law Group, LLP

Primary Examiner:

Utpal D Shah

Assistant Examiner:

Jack Peter Kraynak

Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 21/01 (2006.01); G06V 10/14 (2022.01); G06V 10/25 (2022.01); G06V 10/44 (2022.01); G06V 10/62 (2022.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); G06V 10/14 (2022.01); G06V 10/25 (2022.01); G06V 10/44 (2022.01); G06V 10/62 (2022.01); B01L 2400/0487 (2013.01); G01N 2021/0106 (2013.01);
Abstract

Disclosed herein is a system and method for quantitative detection and analysis of molecular binding kinetics of a substance with surface membrane proteins of a biological object, such as a live cell, based on detecting and tracking membrane fluctuation amplitude changes caused by membrane displacement associated with the binding of the substance with the surface membrane proteins. The molecular binding kinetics can be detected with high precision in real time from an optical image of the biological object with a differential detection method.

Find Patent Forward Citations

Wang, Shaopeng. (2026). Label-free quantification of cell surface membrane protein binding kinetics in biological systems (U.S. Patent No. 12539512). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12539512

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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