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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12535469 B1

PDFFull Text
Date of Patent:
Jan. 27, 2026

Filed:

Feb. 14, 2023

Size exclusion chromatography column technologies for analysis of crispr molecules

Applicant:

Waters Technologies Corporation, Milford, MA (US);

Inventors:

Lavelay Kizekai, Coventry, RI (US);

Stephen Shiner, Holden, MA (US);

Matthew Lauber, North Smithfield, RI (US);

Assignee:

Waters Technologies Corporation, Milford, MA (US);

Attorneys:

WOMBLE BOND DICKINSON (US) LLP

Deborah M. Vernon

Scott R. Breining

Primary Examiner:

David J Bolduc

Int. Cl.
CPC ...
G01N 30/14 (2006.01); B01D 15/34 (2006.01); G01N 30/72 (2006.01); G01N 30/88 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 30/7233 (2013.01); B01D 15/34 (2013.01); G01N 30/14 (2013.01); G01N 30/88 (2013.01); G01N 2030/027 (2013.01); G01N 2030/8831 (2013.01);
Abstract

The present disclosure is directed to methods for performing size exclusion chromatographic (SEC) separations. Embodiments of the present disclosure feature methods for improved separations of biomolecule analytes, such as CRISPR-related proteins, nucleotides, and ribonucleoprotein complexes, in SEC, for example, by using hydroxy-terminated polyethylene glycol surface modified stationary phase materials and/or C/PEG surface modified column hardware.

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Kizekai, Lavelay. (2026). Size exclusion chromatography column technologies for analysis of crispr molecules (U.S. Patent No. 12535469). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12535469

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