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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12534696 B1

PDFFull Text
Date of Patent:
Jan. 27, 2026

Filed:

Apr. 16, 2021

Systems and methods for immobilizing extracellular matrix material on organ on chip, multilayer microfluidics microdevices, and three-dimensional cell culture systems

Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Dongeun Huh, Villanova, PA (US);

Mark Mondrinos, Philadelphia, PA (US);

Cassidy Blundell, Cambridge, MA (US);

Jeongyun Seo, Philadelphia, PA (US);

Assignee:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Attorney:

BakerHostetler

Primary Examiner:

Tracy Vivlemore

Assistant Examiner:

Thomas R. Amick

Int. Cl.
CPC ...
C12M 3/00 (2006.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); C08L 83/04 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 3/06 (2006.01); C12N 5/00 (2006.01); G01N 33/50 (2006.01); G09B 23/30 (2006.01);
U.S. Cl.
CPC ...
C12M 21/08 (2013.01); A61L 27/18 (2013.01); A61L 27/22 (2013.01); A61L 27/3633 (2013.01); A61L 27/3804 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); C08L 83/04 (2013.01); C12M 3/00 (2013.01); C12M 23/00 (2013.01); C12M 23/16 (2013.01); C12M 23/20 (2013.01); C12M 25/02 (2013.01); C12M 25/14 (2013.01); C12M 29/10 (2013.01); C12N 5/0018 (2013.01); C12N 5/0062 (2013.01); C12N 5/0068 (2013.01); G01N 33/5005 (2013.01); G01N 33/5044 (2013.01); G09B 23/30 (2013.01); G09B 23/306 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01); C12N 2535/00 (2013.01); C12N 2537/10 (2013.01);
Abstract

The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4'-azido-2′-nitro-phenylamino)hexanoate ('sulfo-SANPAH'), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.

Find Patent Forward Citations

Quick Actions:

Huh, Dongeun. (2026). Systems and methods for immobilizing extracellular matrix material on organ on chip, multilayer microfluidics microdevices, and three-dimensional cell culture systems (U.S. Patent No. 12534696). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12534696

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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