The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2026
Filed:
Jan. 23, 2020
Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno, 's-Gravenhage, NL;
Arjen Amelink, Gouda, NL;
Mathivanan Damodaran, 's-Hertogenbosch, NL;
Johannes Fitzgerald De Boer, Amstelveen, NL;
Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO, 's-Gravenhage, NL;
Abstract
Methods and systems for measuring hemoglobin concentration (c). A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (λ,λ). The isosbestic wavelengths(λ,λ) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbIO,Hb) have the same molar extinction coefficient. Measurements are collected of a plurality of backscattered reflection intensities (I(χ,λ), I(x,λ), I(χ,λ), I(x,X)). Preferably, the measurements are spectrally resolved at least for the two isosbestic wavelengths (λ,λ) and position-resolved for at least a blood vessel location (x) coinciding with a selected blood vessel and a tissue location (x) coinciding with the retinal tissue without blood vessel. The hemoglobin concentration (c) can be calculated based on a combination of the measurements at the two isosbestic wavelengths (λ,λ).