The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 20, 2026

Filed:

Jun. 03, 2019
Applicant:

Instrumentation Laboratory Company, Bedford, MA (US);

Inventors:

Xiaoxian Xu, Maynard, MA (US);

Prasad Pamidi, Burlington, MA (US);

David Raimondi, Bedford, MA (US);

Miklos Erdosy, Groton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 27/327 (2006.01); B01D 69/12 (2006.01); C12Q 1/00 (2006.01); C12Q 1/54 (2006.01); C12Q 1/58 (2006.01); G01N 27/30 (2006.01); G01N 27/333 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/70 (2006.01); G01N 33/96 (2006.01); G06F 17/18 (2006.01); G06F 30/331 (2020.01); G16B 25/30 (2019.01); G16H 10/40 (2018.01);
U.S. Cl.
CPC ...
G01N 27/3275 (2013.01); B01D 69/12 (2013.01); C12Q 1/002 (2013.01); C12Q 1/003 (2013.01); C12Q 1/005 (2013.01); C12Q 1/54 (2013.01); G01N 27/308 (2013.01); G01N 27/3272 (2013.01); G01N 27/3276 (2013.01); G01N 27/3335 (2013.01); G01N 33/5308 (2013.01); G01N 33/70 (2013.01); G01N 33/96 (2013.01); G06F 17/18 (2013.01); G16B 25/30 (2019.02); G16H 10/40 (2018.01); C12Q 1/58 (2013.01); G01N 27/3274 (2013.01); G01N 33/5438 (2013.01); G06F 30/331 (2020.01);
Abstract

Techniques includes measuring, using a creatine sensor, a creatine sensor current signal (ΔI2) of a first calibration solution (CS2). A creatine sensor sensitivity (Slope) for the creatine sensor is based on the creatine sensor current signal (ΔI2). The first calibration solution (CS2) has a known concentration of creatine (CR_CS2), a known concentration of creatinine (CREA_CS2), and a stable ratio of creatine to creatinine over a range of temperatures for a predefined shelf-life of the first calibration solution (CS2). The Techniques include measuring, using the creatine sensor, a measured creatine concentration (MCR_CS3) of a second calibration solution (CS3). The second calibration solution (CS3) has an initial known creatine concentration (CR_CS3), an initial known creatinine concentration (CREA_CS3), and an unstable ratio of creatine to creatinine that changes over the predefined shelf-life. Concentrations of creatine and creatinine in a sample are thereafter estimated.


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