The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 20, 2026

Filed:

Jul. 31, 2019
Applicants:

Hitachi High-tech Corporation, Tokyo, JP;

Roche Diagnostics Operations, Inc., Indianapolis, IN (US);

Inventors:

Toshiro Saito, Tokyo, JP;

Kyoko Imai, Tokyo, JP;

Francesco Paolucci, Bologna, IT;

Massimo Marcaccio, Bologna, IT;

Giovanni Valenti, Bologna, IT;

Alessandra Zanut, Bologna, IT;

Michaela Windfuhr, Mannheim, DE;

Hans-Peter Josel, Mannheim, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/66 (2006.01); B01L 3/00 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 21/66 (2013.01); B01L 3/502761 (2013.01); G01N 33/54333 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0645 (2013.01);
Abstract

An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.


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