The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 2026
Filed:
May. 01, 2025
Leidos Biomedical Research, Inc., Frederick, MD (US);
Lawrence Livermore National Security, Llc, Livermore, CA (US);
Theras, Inc., South San Francisco, CA (US);
Bin Wang, Dallas, TX (US);
Rui Xu, Dallas, TX (US);
Eli Wallace, Loveland, CO (US);
Zuhui Zhang, Millbrae, CA (US);
David Michael Turner, Frederick, MD (US);
Anna Elzbieta Maciag, Frederick, MD (US);
Dhirendra Kumar Simanshu, Frederick, MD (US);
Albert Hay Wah Chan, Frederick, MD (US);
Tao Liao, Frederick, MD (US);
Christopher John Brassard, Frederick, MD (US);
Yue Yang, Foster City, CA (US);
Paola Bisignano, San Francisco, CA (US);
Felice Lightstone, Fremont, CA (US);
Leidos Biomedical Research, Inc., Frederick, MD (US);
Lawrence Livermore National Security, LLC, Livermore, CA (US);
TheRas, Inc., South San Francisco, CA (US);
Abstract
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.