The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2026
Filed:
Aug. 21, 2020
Midiagnostics NV, Heverlee, BE;
Kris Covens, Leuven, BE;
Willem Van Roy, Leuven, BE;
Tim Stakenborg, Leuven, BE;
Cindy Liu, Baltimore, MD (US);
Jennifer Satterwhite Warden, Timberlake, NC (US);
miDiagnostics NV, Heverlee, BE;
Abstract
The present inventive concept relates to a method for measuring analyte concentration in a sample fluid, comprising: receiving dilution fluid or sample fluid comprising analyte in a microfluidic channel, wherein the dilution fluid or sample fluid further comprises a molecule which is different from the analyte; performing a first affinity-based assay in a first detection zone of the microfluidic channel to measure a signal indicative of the concentration of the molecule in the dilution fluid or sample fluid; mixing the dilution fluid or sample fluid in the microfluidic channel with another of the dilution fluid or sample fluid to obtain a diluted sample fluid; performing a second affinity-based assay in a second detection zone of the microfluidic channel to measure a signal indicative of the concentration of the molecule in the diluted sample fluid; performing a third assay in the second detection zone to measure a signal indicative of the concentration of the analyte in the diluted sample fluid; determining a concentration of the molecule in the received dilution fluid or sample fluid, based on the measured signal of the first affinity-based assay; determining a concentration of the molecule in the diluted sample fluid, based on the measured signal of the second affinity-based assay; and determining the analyte concentration in the sample fluid on basis of the measured signal indicative of the concentration of analyte in the diluted sample fluid and a ratio between the determined concentration of the molecule in the received dilution fluid or sample fluid and the determined concentration of the molecule in the diluted sample fluid. The present inventive concept further relates to a microfluidic arrangement for facilitating measurement of analyte concentration in a sample fluid, and to a system for measuring analyte concentration in a sample fluid, comprising the microfluidic arrangement, and to a diagnostic system comprising the microfluidic arrangement.