The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2026
Filed:
Sep. 05, 2024
Applicant:
Insmed Incorporated, Bridgewater, NJ (US);
Inventor:
Robert Worsham, Bridgewater, NJ (US);
Assignee:
Insmed Incorporated, Bridgewater, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/1277 (2025.01); A61K 31/7036 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1277 (2013.01); A61K 31/7036 (2013.01);
Abstract
Provided herein are large-scale manufacturing methods for drug formulations containing an aminoglycoside such as amikacin. The method utilizes mixing a first stream comprising DPPC and cholesterol with a second stream comprising amikacin sulfate at particular flow rates to obtain a drug formulation with a superior encapsulation efficiency. The processes described herein address the need for preparing aminoglycoside drug formulations at commercial scale.