Method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes

Abstract

The method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient's brain includes: —providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from the epileptic zone to a propagation zone, and loading the models in a computerized platform personalized according to the patient's brain; —providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; —for the at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient's brain, epileptic seizures, and determining, for the hypothesis and epileptic seizures, a network of propagation zones; —for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient's brain, simulated electroencephalographic signals activity to be measured by the intracranial electrodes implanted according to the plurality of schemes; and —determining, from the plurality of schemes, an optimized intracranial implantation scheme of the set of electroencephalographic electrodes.