The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2026

Filed:

Apr. 22, 2021
Applicant:

University of Louisville Research Foundation, Inc., Louisville, KY (US);

Inventors:

Xiaoan Fu, Louisville, KY (US);

Michael Nantz, Louisville, KY (US);

Michael Bousamra, Louisville, KY (US);

Victor Van Berkel, Louisville, KY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/497 (2006.01); A61B 5/08 (2006.01); A61B 5/091 (2006.01); G01N 30/72 (2006.01); G01N 33/543 (2006.01); G01N 33/574 (2006.01); G01N 33/64 (2006.01); H01J 49/00 (2006.01); H01J 49/38 (2006.01);
U.S. Cl.
CPC ...
G01N 33/497 (2013.01); A61B 5/082 (2013.01); G01N 30/72 (2013.01); G01N 33/543 (2013.01); G01N 33/574 (2013.01); G01N 33/57484 (2013.01); G01N 33/64 (2013.01); H01J 49/0031 (2013.01); H01J 49/38 (2013.01); A61B 5/091 (2013.01); A61B 2505/03 (2013.01); G01N 33/4975 (2024.05); G01N 2800/7028 (2013.01);
Abstract

Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for the cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for the cancer in the subject specimen.


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