The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2026

Filed:

Mar. 15, 2019
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Sean M. Wu, Stanford, CA (US);

Jan W. Buikema, Stanford, CA (US);

Arun Sharma, Stanford, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); A61K 35/34 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); A61K 35/34 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2503/02 (2013.01); C12N 2506/45 (2013.01);
Abstract

Methods for expanding beating cardiomyocytes, comprising treating the beating cardiomyocytes with one or more Wnt agonists, one or more bioactive lipids or a combination of one or more Wnt agonists and one or more bioactive lipids. Methods for differentiating stem cells, including iPS cells, into beating cardiomyocytes, comprising treating the iPS cells with a combination of one or more Wnt agonists and one or more bioactive lipids. Compositions and kits for regenerative medicine, comprising beating cardiomyocytes, one or more Wnt agonists and one or more bioactive lipids.


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