The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2026

Filed:

Feb. 02, 2023
Applicants:

The Katholieke Universiteit Leuven, Vlaams-Brabant Leuven, BE;

Springworks Therapeutics Inc., Stamford, CT (US);

Vib Vzw, Ghent, BE;

Inventors:

Bart Vanderhoydonck, Diest, BE;

Arnaud Marchand, Bierbeek, BE;

Wim Smets, Rotselaar, BE;

Aurélie Candi, Werchter, BE;

Matthias Versele, Kessel-Lo, BE;

Assignees:

SPRINGWORKS THERAPEUTICS INC., Stamford, CT (US);

THE KATHOLIEKE UNIVERSITEIT LEUVEN, Leuven, BE;

VIB VZW, Ghent, BE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61P 35/00 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 35/00 (2018.01); C07D 403/04 (2013.01); C07D 471/04 (2013.01);
Abstract

The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds. The present disclosure furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds as well as to said compositions or preparations for use as a medicine, more preferably for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to processes for the preparation of said compounds.


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