The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2026
Filed:
May. 14, 2020
University of Houston System, Houston, TX (US);
Trustees of Tufts College, Medford, MA (US);
Institute for Cancer Research, Philadelphia, PA (US);
Gregory Cuny, Houston, TX (US);
Alexei Degterev, Brookline, MA (US);
Sameer Nikhar, Nashville, TN (US);
Siddharth Balachandran, Elkins Park, PA (US);
Trustees of Tufts College, Medford, MA (US);
University of Houston System, Houston, TX (US);
Institute for Cancer Research, Philadelphia, PA (US);
Abstract
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions.