The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2026

Filed:

Jul. 05, 2022
Applicants:

Bioventures, Llc, Little Rock, AR (US);

The United States of America As Represented BY the Department of Veterans Affairs, Washington, DC (US);

Inventors:

Cesar Compadre, Little Rock, AR (US);

Philip J. Breen, Little Rock, AR (US);

Martin Hauer-Jensen, Little Rock, AR (US);

Kottayil Varughese, Little Rock, AR (US);

K. Sree Kumar, Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/72 (2006.01); C07D 311/58 (2006.01);
U.S. Cl.
CPC ...
C07D 311/72 (2013.01); C07D 311/58 (2013.01);
Abstract

Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the α-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.


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