The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2026
Filed:
Apr. 30, 2020
Shanghai Syncores Technologies Inc. Ltd., Shanghai, CN;
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Yipeng Zhan, Shanghai, CN;
Haisheng Fan, Shanghai, CN;
Kai Yin, Shanghai, CN;
Xiang Ji, Shanghai, CN;
Boyang Liu, Shanghai, CN;
Xiaowen Guo, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Jianguo An, Shanghai, CN;
Hong Gu, Shanghai, CN;
Shanghai SynCores Technologies Inc. Ltd., Shanghai, CN;
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Abstract
Disclosed is a method for preparing a brivaracetam intermediate shown in formula B—R, comprising: reacting a compound shown in formula B—P and a resolving agent to prepare a compound shown in formula B-Q; and converting the compound shown in formula B-Q into the brivaracetam intermediate shown in formula B—R, wherein the resolving agent is a (1S,2S)-(+)-1,2-diaminocyclohexane compound. Also provided is a method for preparing brivaracetam. According to the method, a mixture of two diastereoisomers of(S)-2-3-propylpyrrolidine-1-yl butyric acid can be conveniently and effectively resolved, and the use of a chiral HPLC column is avoided, thereby greatly shortening the process time, simplifying the operation, reducing the process cost, and facilitating industrial production and environmental protection.