The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 06, 2026

Filed:

Apr. 02, 2020
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Christopher Thanos, Cumberland, RI (US);

John Mills, Warwick, RI (US);

Megan Billings, Warwick, RI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61M 31/00 (2006.01); A61F 2/02 (2006.01); A61K 9/00 (2006.01); A61K 35/39 (2015.01); B01D 69/02 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61M 31/002 (2013.01); A61F 2/022 (2013.01); A61K 9/0024 (2013.01); A61K 35/39 (2013.01); B01D 69/02 (2013.01); C12N 5/0676 (2013.01); A61M 2205/04 (2013.01); A61M 2207/00 (2013.01); B01D 2325/0283 (2022.08);
Abstract

Macroencapsulation devices and their methods of use are disclosed. In one embodiment, a macroencapsulation device may include a first outer membrane, a second outer membrane, and at least one semipermeable membrane disposed there between to form at least a primary compartment configured to house a first population of cells and a secondary compartment in fluid communication with the primary compartment through the first semipermeable membrane. In some embodiments, the flow of material into and out of the compartments of the macroencapsulation device and/or the application of an appropriate pressure differential between the compartments may be used to control the flow of filtrates, ancillary agents, and other materials between the compartments of the device when positioned in vivo.


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