The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2026
Filed:
Apr. 06, 2021
Applicant:
Astellas Engineered Small Molecules Us, Incorporated, Cambridge, MA (US);
Inventors:
Santosh S. Kulkarni, Bangalore, IN;
Bharat Lagu, Acton, MA (US);
Xinyuan Wu, Chestnut Hill, MA (US);
Assignee:
Astellas Engineered Small Molecules US, Incorporated, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61P 43/00 (2018.01);
Abstract
One embodiment of the invention is a compound represented by Formula I: or a pharmaceutically acceptable salt thereof. The variables in Formula I are defined herein. Compounds of Formula I are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD+ or to treat a mitochondrial disorder in a subject.