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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12514828 B1

PDFFull Text
Date of Patent:
Jan. 06, 2026

Filed:

Dec. 17, 2024

Methods of permeabilizing the blood brain barrier

Applicant:

University of Southern California, Los Angeles, CA (US);

Inventor:

Thomas Chen, La Canada, CA (US);

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA (US);

Attorney:

Leason Ellis LLP

Primary Examiner:

Kimberly Ballard

Assistant Examiner:

Stacey N Macfarlane

Int. Cl.
CPC ...
A61K 31/045 (2006.01); A61K 9/00 (2006.01); A61K 31/4015 (2006.01); A61K 31/415 (2006.01); A61K 31/4188 (2006.01); A61K 31/4745 (2006.01); A61K 39/395 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 16/42 (2006.01); C12N 5/0783 (2010.01); C12N 5/16 (2006.01); A61K 39/00 (2006.01); C12P 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/045 (2013.01); A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/0078 (2013.01); A61K 9/0085 (2013.01); A61K 31/4015 (2013.01); A61K 31/415 (2013.01); A61K 31/4188 (2013.01); A61K 31/4745 (2013.01); A61K 39/3955 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4211 (2025.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/70503 (2013.01); C07K 16/2809 (2013.01); C07K 16/42 (2013.01); C12N 5/0638 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/543 (2013.01); A61K 2039/544 (2013.01); A61K 2039/545 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); C07K 2317/52 (2013.01); C12N 5/16 (2013.01); C12P 5/007 (2013.01);
Abstract

The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier. The present invention relates to a method of treating a central nervous system (CNS) cancer wherein perillyl alcohol (POH) is administered to a mammal before or concurrently with a therapeutic agent that is a chimeric antigen receptor T-cell (CAR-T cell). The POH and CAR-T cells can be administered by intraarterial injection. The CNS cancer can be a malignant glioma, pilocytic astrocytomas (grade I), meningiomas, metastatic brain tumors, or pituitary adenomas.

Find Patent Forward Citations

Chen, Thomas. (2026). Methods of permeabilizing the blood brain barrier (U.S. Patent No. 12514828). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12514828

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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