The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2025

Filed:

Mar. 27, 2020
Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Jonathan Coffman, Gaithersbury, MD (US);

Scott A. Godfrey, Pleasanton, CA (US);

Raquel Orozco, Richmond, CA (US);

Robert Lee Fahrner, Ellisville, MO (US);

Marcus Andre Fiadeiro, Cambridge, MA (US);

Robert E. Kottmeier, St. Louis, MO (US);

Joseph K. Mclaughlin, Ballwin, MO (US);

Jeffrey Richard Salm, Wakefield, MA (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/00 (2006.01); C12M 1/26 (2006.01);
U.S. Cl.
CPC ...
C12M 23/28 (2013.01); C12M 33/14 (2013.01); C12M 47/10 (2013.01); C12M 47/12 (2013.01);
Abstract

Integrated systems and methods for the manufacturing of recombinant proteins in mammalian cells are provided. The systems and methods include a single-use bioreactor (SUB), a tangential flow filtration system, a column chromatography skid, a tankless hold, a virus inactivation plug flow reactor, and pumps.


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