The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 30, 2025

Filed:

Oct. 28, 2020
Applicant:

Brown University, Providence, RI (US);

Inventors:

Anita Shukla, East Greenwich, RI (US);

Dahlia Alkekhia, Providence, RI (US);

Akram Abbasi, Providence, RI (US);

Assignee:

Brown University, Providence, RI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08J 3/075 (2006.01); A61K 47/69 (2017.01); C12Q 1/04 (2006.01);
U.S. Cl.
CPC ...
C08J 3/075 (2013.01); A61K 47/6903 (2017.08); C12Q 1/04 (2013.01); C08J 2300/208 (2013.01); C08J 2333/26 (2013.01); C08J 2405/16 (2013.01);
Abstract

The invention provides a 'host-guest' supramolecular hydrogel. The hydrogel contains an AAm/NVP interpenetrating polymer network (IPN) with supramolecular cross-linkers assembled from β-lactam/adamantane-containing guest molecule with host polymeric cyclodextrin (PCD). An advantage of this hydrogel is that because of the molecular association of polymeric cyclodextrin and adamantane, the supramolecular hydrogels self-heal without any external stimuli after the hydrogels are severed. The invention also provides methods of making the hydrogel, methods of making the synthesis intermediates, and methods of diagnosis or treatment of β-lactamase-containing bacteria.


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