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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12509444 B1

PDFFull Text
Date of Patent:
Dec. 30, 2025

Filed:

Dec. 04, 2020

Compounds and methods for cd73 modulation and indications therefor

Applicant:

Plexxikon Inc., South San Francisco, CA (US);

Inventors:

Mark Vander Wal, Berkeley, CA (US);

John Buell, San Francisco, CA (US);

Xinping Han, Berkeley, CA (US);

Yongil Jin, New York, NY (US);

Guoxian Wu, Foster City, CA (US);

Songyuan Shi, Fremont, CA (US);

Wayne Spevak, Berkeley, CA (US);

Jack Walleshauser, Berkeley, CA (US);

Jiazhong Zhang, Foster City, CA (US);

Ying Zhang, Fremont, CA (US);

Zuojun Guo, Pasadena, CA (US);

Assignee:

Plexxikon Inc., South San Francisco, CA (US);

Attorney:

Sheppard Mullin Richter & Hampton LLP

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

Richard Grant Peckham

Int. Cl.
CPC ...
C07D 403/04 (2006.01); A61K 31/282 (2006.01); A61K 31/337 (2006.01); A61K 31/396 (2006.01); A61K 31/407 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61K 31/655 (2006.01); A61K 31/664 (2006.01); A61K 31/683 (2006.01); A61K 33/243 (2019.01); A61K 38/20 (2006.01); A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/282 (2013.01); A61K 31/337 (2013.01); A61K 31/396 (2013.01); A61K 31/407 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/655 (2013.01); A61K 31/664 (2013.01); A61K 31/683 (2013.01); A61K 33/243 (2019.01); A61K 38/2013 (2013.01); A61K 38/212 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01);
Abstract

Disclosed are compounds capable of modulating CD73, of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R, R, R, A, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

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