The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2025
Filed:
Feb. 16, 2021
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Matthew D. Shair, Lexington, MA (US);
Daniel E. Jeffries, Lexington, MA (US);
Hanna Tukachinsky, Lexington, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 239/42 (2006.01); A61K 45/06 (2006.01); A61P 35/04 (2006.01); C07D 213/82 (2006.01);
U.S. Cl.
CPC ...
C07D 239/42 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07D 213/82 (2013.01);
Abstract
Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors nicotinamide N-methyltransferase (NNIMT). Also disclosed are pharmaceutical compositions comprising a compound disclosed herein. Related methods of treating cancer in a subject and methods of inhibiting tumor growth in subject are also disclosed.