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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12509424 B1

PDFFull Text
Date of Patent:
Dec. 30, 2025

Filed:

Dec. 11, 2020

Compound and composition as pdgf receptor kinase inhibitor

Applicant:

Nippon Shinyaku Co., Ltd., Kyoto, JP;

Inventors:

Junshi Asada, Kyoto, JP;

Yoshinari Haruta, Kyoto, JP;

Hiroyuki Yakushiji, Kyoto, JP;

Toru Tanaka, Kyoto, JP;

Kazuya Kuramoto, Kyoto, JP;

Keiji Kosugi, Kyoto, JP;

Chiaki Fuchikami, Kyoto, JP;

Assignee:

NIPPON SHINYAKU CO., LTD., Kyoto, JP;

Attorney:
Primary Examiner:

David K O'Dell

Int. Cl.
CPC ...
C07D 213/82 (2006.01); A61K 9/20 (2006.01); A61P 11/00 (2006.01); C07D 213/56 (2006.01); C07D 213/81 (2006.01); C07D 215/12 (2006.01); C07D 239/84 (2006.01); C07D 241/12 (2006.01); C07D 241/20 (2006.01); C07D 263/34 (2006.01); C07D 277/56 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 213/82 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61P 11/00 (2018.01); C07D 213/56 (2013.01); C07D 213/81 (2013.01); C07D 215/12 (2013.01); C07D 239/84 (2013.01); C07D 241/12 (2013.01); C07D 241/20 (2013.01); C07D 263/34 (2013.01); C07D 277/56 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01);
Abstract

An object of the present invention is to provide a compound having a PDGF receptor kinase inhibitory activity. Examples of the present invention may include, for example, a compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof. The compound of the present invention has an inhibitory activity against the PDGF receptor kinase. In addition, since the compound of the present invention has an inhibitory activity against the PDGF receptor kinase, it is useful as a therapeutic agent for respiratory diseases, cancers, smooth muscle proliferative diseases, vasoproliferative diseases, autoimmune/inflammatory diseases, metabolic diseases, vasoocclusive diseases, and the like.

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