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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12508307 B1

PDFFull Text
Date of Patent:
Dec. 30, 2025

Filed:

Nov. 21, 2023

Genetically modified anti-third party central memory t cells and use of same in immunotherapy

Applicant:

Yeda Research and Development Co. Ltd., Rehovot, IL;

Inventors:

Yair Reisner, Houston, TX (US);

Noga Or-Geva, Rehovot, IL;

Eran Ophir, Rehovot, IL;

Yaki Eidelstein, Rehovot, IL;

Rotem Gidron Budovsky, Rehovot, IL;

Assignee:

Yeda Research and Development Co. Ltd., Rehovot, IL;

Attorneys:

PRTSI Inc.

DARRELL HOLLIS

MARTIN MOYNIHAN

Primary Examiner:

Rachel B Gill

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 35/12 (2015.01); A61K 39/395 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61K 40/46 (2025.01); A61K 40/50 (2025.01); A61P 31/00 (2006.01); A61P 35/04 (2006.01); C07K 16/28 (2006.01); C12N 5/078 (2010.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 39/001 (2013.01); A61K 39/39566 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/32 (2025.01); A61K 40/42 (2025.01); A61K 40/4211 (2025.01); A61K 40/46 (2025.01); A61P 31/00 (2018.01); A61P 35/04 (2018.01); C07K 16/2896 (2013.01); C12N 5/0636 (2013.01); C12N 5/0637 (2013.01); C12N 5/0648 (2013.01); A61K 2035/122 (2013.01); A61K 40/50 (2025.01); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); A61K 2239/57 (2023.05); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); Y02A 50/30 (2018.01);
Abstract

An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is described. Methods of generating same and using same are also described.

Find Patent Forward Citations

Reisner, Yair. (2025). Genetically modified anti-third party central memory t cells and use of same in immunotherapy (U.S. Patent No. 12508307). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12508307

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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