The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2025

Filed:

Dec. 21, 2021
Applicant:

The Research Foundation for the State University of New York, Albany, NY (US);

Inventors:

Susan Sharfstein, Niskayuna, NY (US);

Yubing Xie, Cohoes, NY (US);

Pujhitha Ramesh, Albany, NY (US);

James Castracane, Marshfield, NY (US);

Melinda Larsen, Albany, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); D01D 5/00 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01);
U.S. Cl.
CPC ...
C12N 5/0633 (2013.01); D01D 5/0046 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01); C12N 2513/00 (2013.01); C12N 2533/54 (2013.01); C12N 2533/72 (2013.01); C12N 2533/74 (2013.01); C12N 2533/90 (2013.01); C12N 2535/00 (2013.01); D10B 2211/06 (2013.01); D10B 2509/00 (2013.01);
Abstract

The present disclosure relates to compositions, apparatus and methods for generating one or more scaffolds, including: mixing a hydrogel material and/or an extracellular matrix (ECM) protein in an aqueous solvent to generate an aqueous process solution; and cryoelectrospinning the aqueous process solution onto a plurality of conductive probes extending from a conductive surface of a collector plate disposed within a process chamber under conditions sufficient to generate one or more scaffolds configured to mimic a preselected soft tissue decellularized extracellular matrix. Scaffold compositions are also provided having preselected or tuned characteristics.


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