The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2025
Filed:
Oct. 08, 2020
Seismic Pharmaceuticals, Warrington, PA (US);
Alberto Cerri, Milan, IT;
Patrizia Ferrari, Varese, IT;
Mara Ferrandi, Milan, IT;
Paolo Barassi, Castelvaccana, IT;
Giusseppe Bianchi, Milan, IT;
Shih-Che Hsu, Taipai, TW;
Francesco Peri, Milan, IT;
Antonio Zaza, Milan, IT;
Marcella Rocchetti, Brugherio, IT;
Andrea Luraghi, Cerrro Maggiore, IT;
Eleonora Torre, Desio, IT;
Carlotta Ronchi, Milan, IT;
Seismic Pharmaceuticals, Warrington, PA (US);
Abstract
Compounds and compositions for the activation of SERCA2a are disclosed. In particular, provided are compounds that act as predominantly pure or pure SERCA2a activators while only moderately inhibiting the Na/KATPase. In general, the disclosed compounds are derivatives of androstane having the formula (I). Also disclosed herein are pharmaceutical compositions comprising one or more of the compounds of formula (I) for use for the treatment of heart failure.