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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12503467 B1

PDFFull Text
Date of Patent:
Dec. 23, 2025

Filed:

Dec. 09, 2019

2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors

Applicant:

Ideaya Biosciences, Inc., South San Francisco, CA (US);

Inventors:

Muzaffar Alam, South San Francisco, CA (US);

Leah Cleary, South San Francisco, CA (US);

Melissa Fleury, South San Francisco, CA (US);

Zhonghua Pei, South San Francisco, CA (US);

Richard Steel, South San Francisco, CA (US);

James Sutton, South San Francisco, CA (US);

John E. Knox, South San Francisco, CA (US);

Zachary E. R. Newby, South San Francisco, CA (US);

Assignee:

IDEAYA BIOSCIENCES, INC., South San Francisco, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Bong-Sook Baek

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 35/00 (2006.01); C07D 239/80 (2006.01); C07D 239/95 (2006.01); C07D 239/96 (2006.01); C07D 401/02 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 35/00 (2018.01); C07D 239/80 (2013.01); C07D 239/95 (2013.01); C07D 239/96 (2013.01); C07D 401/02 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07B 2200/05 (2013.01);
Abstract

Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

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