The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2025

Filed:

Apr. 21, 2023
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Mark Thomas Miller, Rancho Santa Fe, CA (US);

Dennis James Hurley, San Marcos, CA (US);

Timothy Donald Neubert, San Diego, CA (US);

Vijayalaksmi Arumugam, San Marcos, CA (US);

Sara Sabina Hadida Ruah, La Jolla, CA (US);

Jason Mccartney, Cardiff by the Sea, CA (US);

Jinglan Zhou, San Diego, CA (US);

Jaclyn Chau, San Diego, CA (US);

Robert Martin Demoret, San Diego, CA (US);

Senait G. Ghirmai, San Diego, CA (US);

Roman Askatovich Valiulin, San Diego, CA (US);

Alexander Fredrick Kintzer, Carlsbad, CA (US);

David Robert Slochower, San Diego, CA (US);

Kathleen Aertgeerts, San Diego, CA (US);

Elizabeth Mary Beck, Abingdon, GB;

James Jun Bon Mui, Watford, GB;

Miranda Adele Wright, Oxford, GB;

Ronald Marcellus Alphonsus Knegtel, Abingdon, GB;

Ewa Iwona Chudyk, Wantage, GB;

Joanne Louise Pinder, Didcot, GB;

James Dodd, Wallingford, GB;

Iain Simpson, Oxford, GB;

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 215/233 (2006.01); C07D 239/91 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 215/233 (2013.01); C07D 239/91 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01); C07D 519/00 (2013.01); C07B 2200/05 (2013.01);
Abstract

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.


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