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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12502409 B1

PDFFull Text
Date of Patent:
Dec. 23, 2025

Filed:

Sep. 14, 2021

Composition for preventing or treating inflammatory macrophage-mediated autoimmune disease comprising exosomes derived from stem cells that are surface-modified to target activated macrophages

Applicant:

Research & Business Foundation Sungkyunkwan University, Suwon-si, KR;

Inventors:

Jae Hyung Park, Suwon-si, KR;

Dong Gil You, Suwon-si, KR;

Gyeong Taek Lim, Seoul, KR;

Jae Min Jung, Yongin-si, KR;

Byeong Hoon Oh, Gwangyang-si, KR;

Assignee:

Research & Business Foundation Sungkyunkwan University, Suwon-si, KR;

Attorney:

NSIP Law

Primary Examiner:

Erin M Bowers

Int. Cl.
CPC ...
A61K 35/545 (2015.01); A61K 9/127 (2006.01); A61K 35/15 (2015.01); A61K 35/28 (2015.01); A61K 35/32 (2015.01); A61K 35/50 (2015.01); A61K 35/51 (2015.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61P 19/02 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 35/545 (2013.01); A61K 9/127 (2013.01); A61K 35/15 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61K 35/50 (2013.01); A61K 35/51 (2013.01); A61K 47/549 (2017.08); A61K 47/6911 (2017.08); A61P 19/02 (2018.01); C12N 5/0646 (2013.01);
Abstract

The present invention relates to a composition for preventing, improving and treating an inflammatory macrophage-mediated autoimmune disease, including a stem cell-derived exosome surface-modified with a sugar compound to target an activated macrophage, and the composition according to the present invention may specifically target an activated macrophage to increase the therapeutic efficiency for various types of autoimmune diseases including rheumatoid arthritis. In addition, the composition according to the present invention has a more excellent therapeutic effect and minimizes side effects compared with conventional antiinflammatory agents, stem cell therapeutic agents or exosomes because it contains a gene, protein or growth factor related to the proliferation, differentiation and regeneration of stem cells, and does not include an antibiotic or serum, or harmful factors of the cell culture.

Find Patent Forward Citations

Park, Jae. (2025). Composition for preventing or treating inflammatory macrophage-mediated autoimmune disease comprising exosomes derived from stem cells that are surface-modified to target activated macrophages (U.S. Patent No. 12502409). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12502409

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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