The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 23, 2025
Filed:
Jun. 10, 2024
Nanjing University of Chinese Medicine, Nanjing, CN;
Ming Zhao, Nanjing, CN;
Jinao Duan, Nanjing, CN;
Junfei Zhou, Nanjing, CN;
Lu Fan, Nanjing, CN;
Cai Lu, Nanjing, CN;
Mingming Xu, Nanjing, CN;
Di Di, Nanjing, CN;
Sheng Guo, Nanjing, CN;
Shulan Su, Nanjing, CN;
NANJING UNIVERSITY OF CHINESE MEDICINE, Nanjing, CN;
Abstract
The invention discloses a (9β-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.