The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Sep. 25, 2020
Applicant:

Washington University, St. Louis, MO (US);

Inventors:

Eric Leuthardt, St. Louis, MO (US);

Andy Daniel, St. Louis, MO (US);

Assignee:

Washington University, St. Louis, MO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16H 50/20 (2018.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/48 (2006.01); G06T 7/00 (2017.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01);
U.S. Cl.
CPC ...
G16H 50/20 (2018.01); A61B 5/055 (2013.01); A61B 5/4064 (2013.01); A61B 5/7246 (2013.01); A61B 5/7264 (2013.01); A61B 5/7275 (2013.01); G01R 33/4806 (2013.01); G06T 7/0012 (2013.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); G06T 2207/10088 (2013.01); G06T 2207/30016 (2013.01); G06T 2207/30096 (2013.01);
Abstract

A biomarker predictive of a survival outcome of a brain tumor patient is disclosed. The biomarker includes a functional connectivity matrix that includes a plurality of matrix elements. Each matrix element includes a correlation of resting-state fMRI activities of a first and second region of interest from a plurality of regions of interest within the patient's brain. Computing device and systems are disclosed to transform a resting-state fMRI dataset obtained from the patient into the biomarker and to transform the biomarker into a predicted survival outcome using a machine learning model.


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