The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Apr. 12, 2022
Applicants:

Northeastern University, Boston, MA (US);

The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);

Inventors:

Gregory J. Kowalski, Beverly, MA (US);

Dale N. Larson, Waban, MA (US);

Jason O. Fiering, Boston, MA (US);

Yuwei Zhang, Malden, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 25/20 (2006.01); G01N 1/44 (2006.01);
U.S. Cl.
CPC ...
G01N 25/20 (2013.01); G01N 1/44 (2013.01);
Abstract

A system for calorimetry includes a well having a volume for receiving a sample, an input feature to facilitate reception of the sample in the well, a light source to irradiate the well and the sample with incident light, and a photonic sensor chip disposed at the bottom of the well. The photonic sensor chip includes plural nanohole array (NHA) sensors. A light detector is configured to measure transmission of light through the NHA sensors to obtain a series of extraordinary optical transmission (EOT) measurements. Frame elements secure and mutually couple the light source, the photonic sensor chip, the light detector, and the input feature to form a calorimetry unit. A processor is configured to calculate a calorimetry measurement as a function of the series of EOT measurements, the calorimetry measurement being indicative of energy released as a result of the sample in the well undergoing a change.


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