The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Aug. 16, 2023
Applicant:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Inventors:

Michael Barnes, Oro Valley, AZ (US);

Srinivas Chukka, San Jose, CA (US);

Mohammad Qadri, San Ramon, CA (US);

Assignee:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/00 (2006.01); G01N 1/28 (2006.01); G06T 7/00 (2017.01); G06T 7/33 (2017.01); G01N 1/38 (2006.01);
U.S. Cl.
CPC ...
G01N 1/286 (2013.01); G06T 7/0014 (2013.01); G06T 7/33 (2017.01); G01N 2001/2873 (2013.01); G01N 2001/383 (2013.01); G01N 2800/00 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/30024 (2013.01);
Abstract

The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.


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