The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2025
Filed:
Jan. 24, 2022
Applicant:
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Inventors:
John S. Debenham, Scotch Plains, NJ (US);
Cheng Zhu, Edison, NJ (US);
Amjad Ali, Freehold, NJ (US);
Sung-Sau So, Verona, NJ (US);
Ying-Duo Gao, Middletown, NJ (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/08 (2006.01);
U.S. Cl.
CPC ...
C07D 487/08 (2013.01);
Abstract
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more compounds of Formula I compounds, and methods for using the compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.