The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Mar. 11, 2020
Applicants:

Convergene, Llc, Cambridge, MD (US);

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Jeffrey W. Strovel, Laurel, MD (US);

Makoto Yoshioka, Gaithersburg, MD (US);

David J. Maloney, Point of Rocks, MD (US);

Shyh Ming Yang, Doylestown, PA (US);

Ajit Jadhav, Chantilly, VA (US);

Daniel Jason Urban, Poolesville, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 11/00 (2006.01); A61P 35/00 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 11/00 (2018.01); A61P 35/00 (2018.01); C07D 413/14 (2013.01);
Abstract

The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, including BRD4, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders. In particular, this disclosure provides certain BRD4 inhibitors for the treatment of fibrotic diseases or conditions.


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