The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2025
Filed:
Dec. 06, 2024
Applicants:
Kim Tieu, Miami, FL (US);
Adel Nefzi, Miami, FL (US);
Stephen Black, Miami, FL (US);
Inventors:
Assignee:
The Florida International University Board of Trustees, Miami, FL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 277/42 (2006.01); A61K 31/496 (2006.01); A61P 11/00 (2006.01); A61P 25/16 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 277/42 (2013.01); A61K 31/496 (2013.01); A61P 11/00 (2018.01); A61P 25/16 (2018.01); C07D 417/12 (2013.01);
Abstract
The subject invention provides compounds as Drp1 inhibitors, compositions comprising a Drp1 inhibitor, and methods for inhibiting Drp1 protein using the Drp1 inhibitors. Further provided are methods for treating and/or preventing a disease or condition associated with mitochondrial dysfunction, oxidative stress, inflammation and/or autophagy. Advantageously, the compounds and compositions of the subject invention can also be used to treat a variety of other conditions including, for example, autoimmune disorders, disorders of the nervous system, and cardiovascular disorders.