The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2025
Filed:
Mar. 14, 2022
Applicant:
The Royal Institution for the Advancement of Learning/mcgill University, Montréal, CA;
Inventors:
Jean-Philip Lumb, Montréal, CA;
Colin Crist, Montréal, CA;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07C 335/02 (2006.01); A61P 21/00 (2006.01); C07C 335/16 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C07C 335/02 (2013.01); A61P 21/00 (2018.01); C07C 335/16 (2013.01); C12N 5/0659 (2013.01);
Abstract
The present disclosure relates to a compound of formula (I) where Ris as defined herein. The compound of formula I is an inhibitor of the dephosphorylation of phosphorylated elF2α. The phosphorylation of elF2α affects the quiescence and self renewal properties of stem cells such as muscle stem cells. The compound of formula (I) can thus be used to expand stem cells populations and treat degenerative diseases that have a quiescence regulation affected or mediated by the phosphorylation of elF2α.