The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 16, 2025
Filed:
Apr. 13, 2020
The Johns Hopkins University, Baltimore, MD (US);
Jung Soo Suk, Baltimore, MD (US);
Karina Negron, Baltimore, MD (US);
Justin Hanes, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Non-adhesive brain-permeable nanoparticles as large as 200 nm can diffuse rapidly in the brain ECS preferably made entirely of generally recognized as safe (GRAS) materials having neutral surface charge are described. Synergistic improvement of therapeutic distribution enabled by these non-adhesive, brain-permeable nanoparticles and osmosis-driven brain extracellular matrix (ECM) modulation will significantly enhance drug and gene delivery within the CNS, offering higher drug payload, improved drug loading efficiency, and significantly longer drug release durations.