The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Jul. 31, 2024
Applicant:

Amphastar Pharmaceuticals, Inc., Rancho Cucamonga, CA (US);

Inventors:

Jack Yongfeng Zhang, Rancho Cucamonga, CA (US);

Mary Zi-Ping Luo, Rancho Cucamonga, CA (US);

Ying Wang, Rancho Cucamonga, CA (US);

Ray Lameng Lei, Rancho Cucamonga, CA (US);

Christos Lymberopoulos, Rancho Cucamonga, CA (US);

Tielong Gao, Rancho Cucamonga, CA (US);

Assignee:

Amphastar Pharmaceuticals, Inc., Rancho Cucamonga, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/137 (2006.01); A61K 47/06 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
A61K 9/008 (2013.01); A61K 31/137 (2013.01); A61K 47/06 (2013.01); A61K 47/10 (2013.01); A61K 47/26 (2013.01);
Abstract

Pharmaceutical aerosol formulations containing pre-micronized epinephrine, co-solvent ethanol, surfactant polysorbate 80, and propellant trans-1,3,3,3-tetrafluoropropene (HFO-1234ze(E)) for use in a pressurized metered dose inhaler is described. The formulations provide a highly efficient delivery of pre-micronized epinephrine particles into the patients' respiratory tracts and have the advantages of high efficacy, improved safety, and a low global warming potential (GWP) for environmental impact.


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