The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 16, 2025

Filed:

Dec. 17, 2021
Applicant:

Lightlab Imaging, Inc., Westford, MA (US);

Inventors:

Justin Akira Blaber, Lowell, MA (US);

Ajay Gopinath, Bedford, MA (US);

Wei Chiu, Stony Brook, NY (US);

Assignee:

LightLab Imaging, Inc., Westford, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 5/026 (2006.01); A61B 5/107 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0066 (2013.01); A61B 5/0261 (2013.01); A61B 5/1076 (2013.01);
Abstract

The present disclosure provides systems and methods for determining a mean transit time of a bolus within the blood vessel by passing the bolus through the blood vessel while an intravascular imaging probe is held stationary. The probe may collect a plurality of image frames as the bolus passes the probe. The cross-sectional area of the bolus within the images frames may be determined by segmenting each image frame by thresholding, creating a vessel mask, and creating a contrast mask by applying an element-wise AND operator to the thresholded image and the vessel mask. The cross-sectional area of the bolus for the image frames may be plotted on an area dilution curve. Various fits may be applied to and various points may be identified on the area dilution curve. The various fits and points may be used to determine the mean transit time.


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